Tablet Presentation

Each Film coated controlled release tablet Contains:
Citicoline IP 500/1000 mg

Citicoline is a substance naturally produced by the body and found in cell membranes. It is beneficial in disorders of the brain that affect functions such as movement, memory, mood changes, as it prevents injury to brain cells. It is commonly prescribed as a ‘dietary supplement’ and is available in tablet and injection forms.

Indications

• In mania
• Stroke
• Hypomania
• Cocaine abuse
• Bipolar disorder
• It also decreases the ischaemic lesions

Mechanism of Action

Citicoline is essential for the healthy functioning of the brain. It is present in the cell membranes and is capable of repairing the injured or damaged brain cells. It also helps in minimizing brain damage after any physical injury or due to impaired blood supply or due to old age. The levels are decreased in brain injury, and supplementing it is believed to repair and prevent further damage.

Pharmacokinetics

Absorption- Rapidly absorbed in the gastrointestinal tract. Bioavailability: >90%. Time to peak plasma concentration: 1 hour after oral administration followed by 2nd peak at 24 hours post-dosing.
Distribution- Distributed throughout the body, crosses blood-brain barrier.
Metabolism- Metabolised in the liver and gut wall via hydrolysis to choline and cytidine.
Excretion- Mainly via respiratory CO2 and urine. Elimination half-life: 71 hours (urine); 56 hours (respiratory CO2).

Side Effects

• Diarrhoea
• Stomach pain
• Epigastric discomfort

Contraindications

Hypertonia of the parasympathetic nervous system.

Precautions

Ask your doctor before using it in pregnancy and lactation

Drug Interactions

May potentiate the effect of levodopa.

Disclaimer:The data uploaded is made from content already available on internet.The company holds no right of it and is not responsible for any wrong information.