Methylprednisolone Tablet

Packing Available

Tablet Presentation

Each film coated tablets contains:
Methylprednisolone IP        4 mg
Methylprednisolone IP       8 mg
Methylprednisolone IP       16 mg


Methbylprdnisolone is the glucocorticoid . Mainly it is prednisolone derivative . It has higher potency then prednisone .

Indication

  • Acute gouty arthritis
  • Osteoarthritis
  • In lupus erythematosus
  • Allergic conditions
  • Rheumatoid arthritis
  • Tuberculosis
  • Psoriasis

Mechanism of action

It mainly bound to the phospholipase –A2 which decreases the formation of the arachidonic acid and prevents the production of prostaglandins, also inhibits the NF-kappa B and other inflammatory mediators. It decreases the vasodilation and permeability of the capillaries, also decreases the migration of the leukocyte.corticosteroids bound to the glucocorticoid receptor and causes the changes in the gene expression.

Pharmacokinetics

Absorption: It is orally absorbed.
Protein binding: It is mainly bound to the serum albumin
Metabolism: It undergoes dehydrogenation
Excretion: It excreted both via urine or feces

Side effects

  • Nausea
  • Vomiting
  • Weight gain
  • Headache
  • Confusion
  • Skin problems like eczema, acne
  • Increased thirst
  • Swelling of the lips, feet, ankles

Contraindications:

  • Contraindicated in hypothyroidism
  • Contraindicated in diabetes

Pregnancy

It is only used in pregnancy if benefits outweighs the risk.

Storage conditions

Store it at room temperature.

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