Tablet Presentation

Each film coated tablets contains:
Olmesartan Medoxomil        20 mg
Amlodipine Besilate IP           5 mg

The combination of olmesartan medoxomil and amlodipine is used together in the management of hypertension.


  • Hypertension
  • Rise in blood pressure due to diseases like stroke, kidneys problems, heart attacks
  • Type -2 diabetes associated with nephropathy
  • used in angina pectoris
  • coronary artery disease

About composition

Olmesartan medoxomil:

Olmesartan medoxomil belongs to the class of angiotensin - 2 receptor blocker. It is used in the management of the hypertension.


Amlodipine is the calcium channel blocker which blocks the calcium channel. It belongs to the class of dihydropyridine calcium channel blocker. It lowers the incidence of myocardial depression.

Mechanism of action

Olmesartan medoxomil:

olmesartan blocks the RAAS system which plays important role in maintaining hemostatis , regulation of the kidney , vascular functions . olmesartan inhibits activation of RAAS system by blocking the AT1 receptor which inhibits binding of the angiotensin to angiotensin receptor i.e AT1 and prevents the angiotensin -2 mediated effects such as vasoconstriction, synthesis of aldosterone , renal absorption of sodium .


It inhibits the influx of calcium channel into the vascular smooth muscle and cardiac muscle. Amlodipine dilates the peripheral arterioles , reduces the peripheral resistance.


Olmesartan medoxomil:

Absorption – Its absorption is rapid and complete from the GI tract
Protein binding – It is about 99% bound to plasma proteins
Metabolism – It is metabolized to olmesartan and undergoes ester hydrolysis
Excretion – It is excreted unchanged in the urine.


Absorption - It is absorbed from the GIT
Protein binding - It is about 98% bound to plasma proteins
Metabolism - It is metabolized in the liver.
Excretion - It is excreted in the urine.

Side effects

  • Decrease urination
  • Mild headache
  • Increase heart rate
  • Somnolence
  • Flushing of the face
  • Dizziness
  • Palpitations


  • Contraindicated in patients with hypersensitivity
  • Contraindicated in pregnant women
  • Contraindicated in renal artery stenosis


Store it at 15°C to 30°C
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