Tablet Presentation

Each film coated tablets contains:

Lornoxicam 4/8 mg Paracetamol IP 325 mg

This composition together used to treat mild pain and fever.

Indication

• In arthritis
• Pain relief
• fever

About composition

Paracetamol:

Paracetamol is known as acitominophen which is a pain releiver and fever reducer.

Lornoxicam:

Lornoxicam belongs to the class of non- steroidal anti-inflammatory drugs. It shows analgesic, antipyretic , anti-inflammatory properties. It act as potent inhibitor of prostaglandin synthesis.

Mechanism of action

Paracetamol:

Paracetamol is a weak inhibition of COX-1 and COX-2, further inhibiting prostaglandins synthesis.

Lornoxicam:

It inhibits the synthesis of prostaglandins and thromboxanes synthesis by inhibiting the enzyme cox-1 and cox-2.

Pharmacokinetics

Absorption- Both the drugs are orally absorbed from the GIT
Protein binding- Lornoxicam is mainly bound to albumin i.e upto 99.9% whereas paracetamol do not show protein binding
Metabolism- Lornoxicam is converted into 5-hydroxy lornoxicam
Excretion- Both are excreted via urine

Side effects

• yellowing of skin and eyes
• Nausea
• Diarrhea
• Dark urine
• Headache
• Gas
• Heartburn

Contraindications

• Contraindicated in pregnancy
• In gastrointestinal bleeding
• Contraindicated in acute liver failure, heart diseases