Each film coated tablets contains:
|Lornoxicam 4/8 mg |
Paracetamol IP 325 mg
This composition together used to treat mild pain and fever.
- Pain relief
Paracetamol is known as acitominophen which is a pain releiver and fever reducer.
Lornoxicam belongs to the class of non- steroidal anti-inflammatory drugs. It shows analgesic, antipyretic , anti-inflammatory properties. It act as potent inhibitor of prostaglandin synthesis.
Mechanism of action
Paracetamol is a weak inhibition of COX-1 and COX-2, further inhibiting prostaglandins synthesis.
It inhibits the synthesis of prostaglandins and thromboxanes synthesis by inhibiting the enzyme cox-1 and cox-2.
Both the drugs are orally absorbed from the GIT
Lornoxicam is mainly bound to albumin i.e upto 99.9% whereas paracetamol do not show protein binding
Lornoxicam is converted into 5-hydroxy lornoxicam
Both are excreted via urine
- yellowing of skin and eyes
- Dark urine
- Contraindicated in pregnancy
- In gastrointestinal bleeding
- Contraindicated in acute liver failure, heart diseases