Tablet/Capsule Presentation
Each film coated tablets contains:
Thiocolchicoside IP 4 mg
Thiocolchicoside IP 8 mg
Thiocolchicoside is the semi-synthetic derivative of colchicine.it is used as muscle relaxant and also have anti- inflammatory property, analgesic property. It is obtained from the seed of plant superba gloriosa.
Therapeutic indications
- In Orthopaedics
- Rheumatoid disorders
- Prevents painful muscles contractions
Mechanism of action
Thiocolchicine mediates its effect by binding with the GABA receptor which is inhibitory neurotransmitter and activate it. It also activates the glycine receptors and prevents the muscle contraction by activating the GABA and promotes muscle relaxation.
Pharmacokinetics
Absorption:
It is orally absorbed.
Plasma proteins:
It is bound to serum protein i.e albumin
Metabolism:
It metabolized to active and inactive metabolites i.e 3-demethylcolchicine, 3-O-glucurono-demethylcolchicine (active metabolite) or didemethylcolchicine (inactive metabolite)
Excretion:
Excretion takes via urine and feces
Side effects
- Nausea
- Allergy
- Vasovagal Reactions
Contraindications
- Contraindicated in patients with known hypersensitivity
- Contraindicated in pregnant women