Tablet Presentation

Each film coated tablets contains:
Aceclofenac IP                100 mg
Thiocolchicoside IP       4 mg

Aceclofenac IP                100 mg
Thiocolchicoside IP       8mg

Aceclofenac is the non -steroidal anti-inflammatory drug.It has anti-inflammatory and analgesic properties and is used to treat osteoarthritis , rheumatoid arthritis , ankylosing spondylitis. Thiocolchicoside is the semi-synthetic derivative of is used as muscle relaxant and also have anti- inflammatory property, analgesic property. It is obtained from the seed of plant Superba gloriosa.
This combination is used together to relieve pain and muscle spasm.


  • In Orthopaedics
  • Rheumatoid disorders
  • Prevents painful muscles contractions

Mechanism of action

Aceclofenac exerts its effect by inhibiting the cox-2 enzyme which is responsible for the synthesis of prostaglandin analogues that produce inflammation. Thiocolchicine mediates its effect by binding with the GABA receptor which is inhibitory neurotransmitter and activate it. It also activates the glycine receptors and prevents the muscle contraction by activating the GABA and promotes muscle relaxation.



Absorption- It is rapidly absorbed from GIT
Protein binding- It is 99% bound to plasma protein
Metabolism- It is metabolized to 4- hydroxyaceclofenac
Excretion - It is excreted via urine.


Absorption: It is orally absorbed.
Plasma proteins: It is bound to serum protein i.e albumin
Metabolism: It metabolized to active and inactive metabolites i.e 3-demethylcolchicine, 3-O-glucurono-demethylcolchicine (active metabolite) or didemethylcolchicine (inactive metabolite)
Excretion: Excretion takes via urine and feces

Side effects

  • Nausea
  • vomiting
  • epigastric pain
  • Heartburn
  • diarrhea
  • Vasovagal Reactions


  • Contraindicated in patients with known hypersensitivity
  • Contraindicated in pregnant women
  • Contraindicated in arthritis, asthma
  • Contraindicated in hepatic and renal failure

Storage conditions

Store this combination in cool and dry place below 25°C.
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