Each film coated tablets contains:
Omeprazole Magnesium IP 10 mg
Ondansetron Hydrochloride IP 4 mg
proton pump inhibitor. It is used to treat gastric acid related disorders such as gastroesophageal reflux disease, peptic ulcer and over secretion of gastric acid. It is very effective among other PPI 's and is well tolerated .
is the serotonin 5HT3 antagonist.It is used in the treatment of the Vomiting and nausea
This combination is used to treat chemotherapy induced nausea and vomiting.
Mechanism of Action
It mainly blocks the 5HT3 receptors located in the nerve terminals in the vagus in the periphery and in the chemotrigger zone, area of postrema .
Hcl production is regulated by H+ K+ ATPase of the protein pump inhibitor present in the parietal cells so omaprazole covalently bind to cysteine residue of the alpha subunit of the H+ K+ ATPase pump and inhibits the over production of hcl.
It is absorbed by oral route.
It is about 73% bound to plasma proteins.
It is metabolized in the liver with the help of cytochrome enzymes and undergoes conjugation and hydroxylation.
It is excreted by urine in unchanged form
omeprazole is rapidly absorbed from the stomach.
omeprazole is about 95% bound to plasma proteins.
It is metabolized in the liver.
It is eliminated from the urine and rest of the drug is excreted via feces.
Contraindicated in people with known hypersensitivity.
It is stored at room temperature