Each film coated tablet contains:
Lansoprazole IP 15 mg
Lansoprazole IP 30 mg
- Lansoprazole is the proton pump inhibitor and structurally is the Substituted benzimidazoles . It reduces the excessive gastric acid production by inhibiting the H+ K+ ATPase activity.
- It do not effect the enzyme pepsin and juice motility, gastric motility.
- It is more potent then than the omeprazole
- Peptic ulcer
- Bleeding peptic ulcer
- Stress ulcers
- Gastroesophageal reflux disease
- Zollinger- Ellison syndrome
- Aspiration pneumonia
Mechanism of Action
Lansoprazole rearranges itself in the cationic form i.e is sulphenic acid and sulphenamide which then reacts with the SH groups of the H+K+ATPase and inactivate the pump.
It is orally absorbed, its absorption delays with the intake of food.
It is about 97% bound to serum proteins.
It is metabolized in the liver to 5- hydroxy lansoprazole and to sulphone derivative of the lansoprazole.
It is excreted via urine.
- Loose stools
- Abdominal pain
- Muscle and joint pain
- Contraindicated in the people with the known hypersensitivity.
- Contraindicated in gastric cancer
- Contraindicated in rebound acid hypersecretion
- Contraindicated in the hepatic disease
- Contraindicated in pregnancy
Store it at room temperature.