Lansoprazole Tablet

Packing Available

Tablet Presentation

Each film coated tablet contains:
Lansoprazole IP           15 mg
Lansoprazole IP           30 mg

  • Lansoprazole is the proton pump inhibitor and structurally is the Substituted benzimidazoles . It reduces the excessive gastric acid production by inhibiting the H+ K+ ATPase activity.
  • It do not effect the enzyme pepsin and juice motility, gastric motility.
  • It is more potent then than the omeprazole

Indications

  • Peptic ulcer
  • Bleeding peptic ulcer
  • Stress ulcers
  • Gastroesophageal reflux disease
  • Zollinger- Ellison syndrome
  • Aspiration pneumonia

Mechanism of Action

Lansoprazole rearranges itself in the cationic form i.e is sulphenic acid and sulphenamide which then reacts with the SH groups of the H+K+ATPase and inactivate the pump.

Pharmacokinetics

Absorption: It is orally absorbed, its absorption delays with the intake of food.
Protein binding: It is about 97% bound to serum proteins.
Metabolism: It is metabolized in the liver to 5- hydroxy lansoprazole and to sulphone derivative of the lansoprazole.
Excretion: It is excreted via urine.

Side Effects

  • Nausea
  • Loose stools
  • Abdominal pain
  • Muscle and joint pain
  • Dizziness
  • Rashes

Contraindication

  • Contraindicated in the people with the known hypersensitivity.
  • Contraindicated in gastric cancer
  • Contraindicated in rebound acid hypersecretion
  • Contraindicated in the hepatic disease
  • Contraindicated in pregnancy

Storage

Store it at room temperature.
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