DRY SYRUP Presentation

Each 5ml contains:
Cefixime Trihydrate IP 50 mg
Ofloxacin IP 50 mg


This combination of cefixime and ofloxacin used to treat the infections caused by bacteria.

Indications

  • Urinary tract infections.
  • Otitis media (inflammation of the middle ear).
  • Gonorrhoeal infections (cervical and urethral infections).
  • In acute bronchitis
  • Used in tonsillitis
  • Used to treat various skin infections
  • Used in kidney infections

About Composition

Cefixime:

Cefixime belongs to third- generation of cephalosporin antibiotic. Cefixime is used widely then other cephalosporins and penicillin because cefixime is resistance to beta- lactamase enzymes. It has bactericidal action and prevent the synthesis of cell wall

Ofloxacin:

Ofloxacin is second- generation fluoroquinolone antibiotic it works by inhibiting the enzyme DNA gyrase and prevents the super-coiling and replication of the DNA of the bacteria

Mechanism of action

Cefixime:

It works by interfere with the cell wall synthesis by inhibiting the enzyme peptidoglycan transferase which prevents the cross-linking of peptidoglycan (NAM & NAG) and kills the bacteria

Ofloxacin:

Ofloxacin works by inhibiting the enzyme DNA gyrase and topoisomerase IV of the bacteria which is similar to the human topoisomerase and thus prevents the super-coiling of DNA during replication or transcription.

Side Effects

  • Nausea
  • Vomiting
  • Indigestion
  • Flatulence
  • Stomach pain
  • Diarrhea

Contraindications

  • Contraindicated in patients with known sensitivity and allergy
  • Contraindicated in hypoglycaemia.
Pregnancy: Use only if needed during pregnancy.

Storage Conditions

Store in air tight containers protected from light at 25℃ or in refrigerator

SHAKE THE BOTTLE WELL BEFORE USE

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