CAPSULE Presentation

Each hard gelatin capsule contains:
Racecadotril BP 100 mg

Racecadotril is the oral enkephalinase inhibitor. It is used in the treatment of the acute diarrhea. It reduces the secretion of the water and electrolytes into the intestine.

Indications

• Acute diarrhea
• Gastroenteritis
• Diarrhea

Mechanism of action

Racecadotril increases the availability of the endogenous enkephalins by inhibiting the enkephalinase which is bound to membrane thus endogenous enkephalinase activates the gamma opiod receptors present in the GI Tract. These leads to the reduction in the level of the cAMP, therefore decreases secretion of the water and electrolytes in the intestinal lumen.

Pharmacokinetics

Absorption: It is rapidly absorbed orally. Protein Binding: It is about 90% bound to serum proteins. Metabolism: It undergoes hydrolysis to thiorphan which is the active metabolite of the racecadotril.
Excretion: It is excreted via urine as well as through feces.

Side Effects

• Tonsillitis
• Rashes on the skin
• Swelling of the lips and face
• Headache
• Shortness of breathing

Contraindications

• Contraindicated in the patients with renal insufficiency
• Contraindicated in the patients with the known hypersensitivity
• Contraindicated in the pregnant and lactating women.

Storage

Store this drug at room temperature.