Each dispersible tablet contains:
Racecadotril BP 10 / 30 mg
Racecadotril (acetorphan) is an oral enkephalinase inhibitor works by preventing the degradation of endogenous enkephalins, racecadotril reduces hypersecretion of water and electrolytes into the intestinal lumen. Racecadotril treatment also results in significant reductions in stool output.
- Acute Diarrhea
- Acute Gastroenteritis
Mechanism of action
The active metabolite of racecadotril, thiorphan, inhibits enkephalinase enzymes in the intestinal epithelium , protecting enkephalins from being broken down by these enzymes. This reduces diarrhea related hypersecretion in the small intestine without influencing basal secretion. Racecadotril also has no influence on the time substances, bacteria or virus particles stay in the intestine.
It is rapidly absorbed after oral administration
Cmax reaches within 60 minutes
Presence of food delays the absorption.
Volume of Distribution:
90% of the drug is bound to plasma protein
Mainly metabolised in liver to form active metabolite called thiorphan.
Metabolites are mainly excreted in urine and very few amount is excreted in feces
Half-life of racecadotril is avout three hours.
- Skin rash
- swelling of face and lips
- Difficulty to breath
- This medicine is not recommended for pregnant women.
- This medicine is not recommended for breastfeeding women.
- The treatment should be discontinued if any symptoms of skin reactions appear.
- Dose should be adjusted in patients with renal insufficiency.