Capsule Presentation

Each capsule contains:
Acebrophylline 100 mg

Acebrophylline is an effective bronchodilator medicine used to treat blockage, swelling, and irritation associated with bronchial asthma and chronic obstructive pulmonary disease (COPD) in adults.

Indications

• Asthma
• Chronic obstructive pulmonary disease

Mechanism of Action

Acebrophylline inhibits intracellular phosphodiesterase associated with cAMP levels and facilitates bronchial muscles relaxation. Acebrophylline selectively inhibits phosphatidylcholine and phospholipase A, TNF-alpha and leukotrienes. Inhibition of such pro-inflammatory mediators can significantly reduce the airway inflammation and obstruction in chronic stages.

After oral administration, the drug is rapidly absorbed in the stomach and Cmax can be reached within two hours. The plasma half-life of Acebrophylline varies from 4-9 hours. The drug is primarily metabolized in the liver and eliminated via the urine.

Side Effects

• Glycosuria
• Epigastric pain
• Low blood pressure
• GI discomfort or distension
• Anorexia, drowsiness
• Breathing difficulties
• Hyperglycemia
• Mild skin reactions
• Fever
• Fatigue
• Nasal inflammation.

Contraindications

• Hypotension
• Acute myocardial infarction
• Impaired hemodynamics
• Hepatic or/and renal disorders
• Ambroxol allergy
• Convulsion
• Arrhythmia
• Cardiac insufficiency
• Hyperthyroidism
• Pregnancy
• Lactation