TABLET Presentation

1.Each film coated tablet contains:
Diclofenac Sodium IP 50 mg
Thiocolchicoside IP 8 mg

2. Each film coated tablet contains:
Diclofenac Sodium IP 50 mg
Thiocolchicoside IP 4 mg


Diclofenacis phenylacetic acid derivative and non -steroidal anti -inflammatory drug Diclofenac inhibit cox -1 and cox-2 enzyme and prevents the synthesis of prostaglandins
Thiocolchicoside is the semi-synthetic derivative of colchicine . it is used as muscle relaxant and also have anti- inflammatory property, analgesic property. It is obtained from the seed of plant Superba gloriosa.
This combination is used to relieve pain associated with muscle spasm

Indications

  • As muscle relaxant
  • Joint pain
  • Fever

Mechanism of action

Diclofenac inhibits the synthesis of prostaglandins by inhibiting the cox-1 and cox-2 enzyme and prevents the formation of PGG2 which the precursor for the synthesis of other prostaglandins.
Thiocolchicoside mediates its effect by binding with the GABA receptor which is inhibitory neurotransmitter and activate it. It also activates the glycine receptors and prevents the muscle contraction by activating the GABA and promotes muscle relaxation.

Pharmacokinetics

Absorption- Both the drugs are orally absorbed from the GIT
Protein binding- Both the drugs mainly bound to serum albumin
Metabolism- diclofenac undergoes oxidation and conjugation whereas thiocolchicoside is metabolized to active and inactive metabolites i.e 3-demethylcolchicine, 3-O-glucurono-demethylcolchicine (active metabolite) or didemethylcolchicine (inactive metabolite)
Excretion- Diclofenac is excreted via urine whereas thiocolchicoside is excreted both by urine and via feces

Side effects

  • yellowing of skin and eyes
  • Nausea
  • vomiting
  • Diarrhea
  • Heartburn
  • Anorexia
  • Epigastric pain

Contraindications

  • Contraindicated in patients with known hypersensitivity
  • Contraindicated in pregnant women
  • Contraindicated in arthritis, asthma
  • Contraindicated in hepatic and renal failure
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