Tablet Presentation

Each uncoated tablet contains:
Terbinafine Hydrochloride BP
equivalent to Terbinafine 250 mg
( in Betacyclodextrin )

Terbinafine is the synthetic antifungal.It fights against the infections caused by the fungus that mainly effect the nails of fingers and toe.

Indications and Usage

• Used in the treatment pityriasis versicolor
• Fungal nail infections
• Jock itch
• Athlete’s foot

Mechanism of Action

It works by inhibiting the ergosterol synthesis by inhibiting the enzyme squalene epoxidase which is essential for the fungal cell wall synthesis.

Pharmacokinetics

Absorption: It is absorbed by oral route of administration
Protein binding: It is mostly bound to serum albumin i.e about 99% and to low density lipoproteins to lesser extend Metabolism: It undergoes N- demethylation to desmethylterbinafine
Excretion: It excreted about 80% via urine and rest of the drug is excreted by feces

Side Effects

• Dizziness
• Rashes
• Nausea
• Vomiting
• Abdominal pain
• Frequent urination

Contraindications

• Contraindicated in patients with known hypersensitivity
• Contraindicated in patients with chronic and acute liver diseases

Storage

Store it at room temperature.

Caution

Terbinafine is cautiously used in pregnant women