Each Uncoated Dispersible Tablet Contains:
Aciclovir IP 400 mg
It is nucleotide analog basically. It is used in the treatment of herpes simplex, varicella zoster and in acute herpes keratitis. It works on the enzyme deoxyribonucleic acid polymerase and process of DNA replication.
- Bell’s palsy
- Herpes simplex infection
- Acute herpetic keratitis
- Severe genital herpes
Mechanism of Action
Aciclovir is firstly converted into Aciclovir monophosphate and Aciclovir diphosphate or triphosphate with the help of the enzyme thymidine kinase & guanylate kinase or nucleoside diphosphate kinase, Aciclovir triphosphate binds to the viral DNA polymerase and then inactivates them.
It is absorbed more by oral route when given orally but it shows less absorption when used topically
It shows up to 33% of protein binding.
It undergoes oxidation
It is excreted unchanged via urine
- Hair loss
- Contraindicated in people with known hypersensitivity
- Contraindicated in renal impairment
Non-steroidal anti-inflammatory drug
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