Each Uncoated Tablet Contains:
Cinnarizine IP 25 mg
Cinnarizine is the antihistaminic medication. It is the calcium channel blocker that presents on the vestibular apparatus and blocks the signal transmission between the vestibular apparatus of the inner ear and vomiting centre of the hypothalamus.
Cinnarizine has vasorelaxating properties due to the blockage calcium channel.
Indications & Usage
- Used in vertigo/ meniere,s disease
- Motion sickness
- Travel sickness
Mechanism of Action
Cinnarizine is the H1 and calcium channel blocker, as the histamine causes contraction of the smooth muscles of airways and gastrointestinal tract , vasodilation , cardiac stimulation , secretion of gastric acid , promotion of interleukin release and eosinophils.
Cinnarizine mainly blocks H1 receptor and muscarinic receptor therefore stimulates the inhibition of the vestibular apparatus, also inhibits the voltage gated L – type and T- type voltage gated calcium channels.
- Dry mouth
- Gastrointestinal irritation
- Hypersensitivity reaction
- Muscles rigidity
- Contraindicated in people with depression.
- Contraindicated in Parkinson’s disease.
Not recommended to take during pregnancy.
Store it at room temperature.