Each Gastro-Resistant Tablet contains:
Duloxetine hydrochloride USP
Eq. to Duloxetine 20 mg
Duloxetine is the serotonin reuptake inhibitors. It is used in the treatment of depressive disorders.
Indications & Usage
- Stress incontinence
- Anxiety disorders
- Pain in cancer, surgery
Mechanism of Action
Duloxetine increases the concentration of the serotonin and norepineprhine and enhances the activation of the glutamates receptor, it increases the activation of the 5HT2, 5HT3 also increases the activity of phospholipase CWhich then further increases the intercellular calcium, which causes the excitability of neuron.
Duloxetine is absorbed orally
It is mainly bound to the alpha-1 acid glycoprotein and albumin
It undergoes glucuronide conjugation
It is excreted via feces
Contraindicated in cross angle glaucoma
Only be used if potential benefits outweighs the risk