Dutasteride Tablet

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Tablet Presentation

Each Tablet Contains:
Dutasteride       0.5 mg

Dutasteride is the 5- alpha reductase inhibitor. It is used to treat enlarged prostate gland .it is also used in men to prevent hair loss.

Indications

  • Enlarged prostate
  • In prostate Hyperplasia
  • Reduces the risk of urinary retention

Mechanism of Action

Dutasteride prevents the conversion of the testosterone to dihydrosterone by inhibiting the enzyme 5-alpha reductase , as dihydrotesterone causes enlargement of the prostate gland.

Pharmacokinetics

Absorption: It is orally absorbed
Protein binding: It is about 99.9% bound to serum albumin and 96.8% bound to alpha-1 acid glycoprotein
Metabolism: It is metabolized in the liver to 4, 5 hydroxydutasteride
Excretion: Excreted via kidney

Side effects

  • Impotence
  • Tenderness in breast and increase in breast size
  • Swelling and pain in the testicles

    Contraindications

    • Contraindicated in patients with renal impairment
    • Contraindicated in patients with known hypersensitivity
    • Contraindicated in pregnant women

    Storage

    Store it at 20°C to 25°C
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