Capsule Presentation

Each Capsule Contains:
Fluoxetine IP 20 mg

It is 2nd generation antidepressant drug belongs to the class of selective serotonin reuptake inhibitor . It is used for the management of acute depressive disorder, obsessive compulsive disorder . Fluoxetine is used in combination with olanzapine to treat bipolar disorder and resistant depression.

Indications

• Used in the treatment of panic disorder (agrophobia).
  
• Obsessive compulsive disorder.
• Bulimia nervosa.
• Depression

Mechanism of Action

Fluoxetine inhibits the presynaptic neuron reuptake of serotonin by binding with 5HT2 receptor and thus increases the level of the 5-HT in the brain.

Pharmacokinetics

Absorption: is is absorbed orally.
Protein binding: it is highly protein bound.
Metabolism: it is metabolized to norfluoxetine and then undergoes glucuronide conjugtion .
Excretion: fluoxetine is excreted via urine.

Contraindication

• Contraindicated in mania
• Contraindicated in people with low sodium level
• In diabetes.

Side Effects

• Headache
• Insomnia
• Dry mouth
• Stomach upset
• Nervousness
• Tremors
• Dizziness

Storage

Fluoxetine is store at 15°C to 30°C.

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