Each Uncoated Tablet Contains:
Metformin Hydrochloride(as Prolonged Release) IP 500 mg
This composition is used together for the lowering the risk of decrease in blood sugar level i.e. hypoglycaemia which occurs due to single use of glimepiride which can be adjusted by using it with metformin.
In type-2 diabetes mellitus
Metformin belongs to the biguanides class. It is antihyperglycemic drug and is used in the treatment of the Type-2 diabetes mellitus.
It does not cause hypoglycaemia which is the side effect of other antihyperglycemic drugs
Metformin decreases the insulin resistance
It is very effective when taken during exercise and with diet
Glimepiride is known as insulin secretagogue. It improves the glycaemic control
It lowers the blood glucose level.
Mechanism of Action
Metformin decreases the production of glucose by liver and prevents the intestinal absorption of glucose
Also enhances the insulin sensitivity by increasing peripheral glucose uptake and utilization.
Glimepiride binds to SUR receptors blocks the ATP sensitive potassium channels and causes depolarization of beta cells.
It is absorbed orally and d not show protein binding and metabolism. it is excreted unchanged in the urine.
It is orally absorbed and it is 99% bound to plasma proteins
It undergoes oxidation and excreted via urine
- Weight gain
- Contraindicated in renal dysfunction
- Contraindicated in people with known hypersensitivity
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