Ondansetron Tablet

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Tablet Presentation

Each uncoated orally disintegrating tablet contains:
Ondansetron IP 8 mg

Ondansetron is the serotonin receptor antagonist. It selectively blocks 5HT3 receptors. It is mainly used to treat nausea and vomiting caused by cytotoxic drugs anti- cancerous agent.

Indications & Usage

  • Mostly used in paediatric population for the treatment of post-radiotherapy induced nausea and vomiting.
  • Treats nausea and vomiting induced during chemotherapy
  • Cholestatic pruritis
  • Uremic pruritis

Mechanism of Action

  • It selectively blocks 5HT3 receptors located in the nerve terminal of the vagus in periphery and centrally in the chemotrigger zone of area postrema.
  • It also blocks the serotonin released from the enterochromaffin cells located in the small intestine as these cells initiates vomiting reflex and causes nausea and vomiting


Absorption- It is absorbed orally
Protein Binding- It is 73% bound to serum proteins
Metabolism- It is metabolized in the liver
Excretion- It is excreted via urine and through feces

Side Effects

  • Dizziness
  • Drowsiness
  • Tiredness
  • Constipation
  • Headache


Contraindicated in people with known hypersensitivity.


Stop taking it if you have any one of the symptoms such as rashes, itching, hoarseness and swelling.
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