Each uncoated tablet contains:
Repaglinide IP 0.5 mg
Repaglinide is the oral hyperglycemic drug, belongs to the class of meglitinide analogues. It is used for non – insulin dependent diabetes mellitus. It helps to reduces postprandial sugar.
Mechanism of Action
Repaglinide acts on the beta cells and blocks the ATP sensitive potassium channel and causes depolirization and open up the calcium channel, calcium causes degranulation of insulin thus increases insulin sensitivity
It is completely absorbed by oral route
It is about 98% bound to the plasma proteins mainly to albumin and alpha acid glycoprotein
It undergoes oxidation and dealkylation
Mainly excreted via feces and to a lesser extent by urine
- Weight gain
- Joint pain
- Contraindicated in pregnancy
- Contraindicated in patients with known hypersensitivity
Store it at room temperature.