Tablet Presentation

Each uncoated bilayered tablet contains:
Telmisartan IP 80 mg
Amlodipine Besylate IP    Eq. to  Amlodipine 5 mg
Hydrochlorothiazide IP 12.5 mg

This combination is mainly used to treat heart problems such as blood pressure and helps to prevent strokes, heart attacks and kidney problems.


  • Hypertension
  • Oedema
  • Stroke
  • Chronic heart failure

About Composition


Telmisartan belongs to angiotensin receptor blocker. It is used in the treatment of hypertension.
It reduces the pressure generated in the arteries

Amlodipine Besylate-

Amlodipine besylate have an antioxidant property which stimulate the production of nitric acid and acts as vasodilatory effect which lowers the blood pressure.


It is thiazide diuretic and is commonly used in the treatment of oedema and hypertension.
It can be given in combination to treat heart failure, hepatic cirrhosis and chronic renal failure.

Mechanism of Action

Telmisartan inhibits the binding of angiotensin with AT1 receptors thus prevents its conversion to aldosterone and counterattack its vasoconstrictor action.
Amlodipine besylate binds to the calcium channels and blocks them and dilates the peripheral vessels an maintains cardiac muscles functions.
Hydrochlorothiazide inhibits the sodium chloride symporter in the distal convoluted tubule.



It is absorbed orally
It is 99% bound to plasma proteins
It undergoes glucuronidation conjugation
It is excreted via urine


It is absorbed orally
It is 98% bound to plasma proteins
It is metabolized in the liver
It is excreted via urine


Absorption- It is absorbed orally
Protein Binding- It is binds to serum albumin
Excretion- It is excreted via urine

Side Effects

  • Muscle pain
  • Tenderness
  • Weakness
  • Fever
  • Nausea
  • Dark coloured urine


  • Contraindicated in diabetes mellitus
  • Contraindicated in renal impairment
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