Tablet Presentation

Each uncoated bilayer tablet contains:
Teneligliptin Hydrobromide Hydrate IP
Equivalent to Teneligliptin 20 mg
Metformin Hydrochloride  (as sustained release ) IP 500 mg


Diabetes may cause many complications and causes disability, reduces the quality of living and premature death.so, this composition offers benefits and effectively treats short term and long-term complications.

Indications

In type-2 diabetes mellitus

About Composition

Teneligliptin-

Teneligliptin is a dipeptidyl peptidase 4 inhibitor. It is used along with exercise and diet for the control of blood sugar level

Metformin Hydrochloride-

Metformin is a biguanide and it prevents the damage of kidney and blindness and problems in nerves, loss of limbs and sexual functional problems.

Mechanism of Action

Teneligliptin-

It increases the release of insulin from the pancreas and causes the decrease in the release of hormone that raises the blood sugar levels.

Metformin-

It delays the absorption of glucose from the intestine and increases the sensitivity to insulin or lowers the production of glucose from liver.

Pharmacokinetics-

Absorption- It is absorbed via GIT
Protein Binding- It is 90% bound to plasma proteins
Metabolism- It is metabolized in the liver
Excretion- It is excreted via urine

Side Effects

  • Nausea
  • Vomiting
  • Stomach upset
  • Sore throat
  • Congestion of nose

Contraindications

  • Contraindicated in people with renal impairment
  • Contraindicated in people with known hypersensitivity

Drug Interactions

  • Atenolol
  • Metoprolol
  • Vandetanib
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