Tablet Presentation

Each Uncoated Dispersible Tablet contains:
Cefixime Trihydrate IP 50 mg
Cefixime Trihydrate IP 100 mg
Cefixime Trihydrate IP 200 mg

Chemical formula

(6R,7R)-7-{[2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino}-3-ethenyl-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cefixime Trihydrate is a cephalosporin antibiotic used to treat infections caused by bacteria such as pneumonia; bronchitis; gonorrhea; and ear, lung, throat, and urinary tract infections.

Indications

• Upper Respiratory Tract Infections
• Middle Ear Infections
• Urinary Tract Infections
• Uncomplicated gonorrhea
• Paranasal sinuses
• Otitis media
• Throat infections

Pharmacokinetics

Cefixime are absorbed after oral administration. others can be administered either i.v (intra venous) or i.m (intra muscular) cefotaxime, ceftriaxoneand ceftizoxime(3rd gene) penetrate into cerebrospinal fluid and are useful in meningitis.All cephalosporins cross placenta.cefoperazoneis found in high,concentration inbile.cefexime,is excreted through kidney, dosage should be adjusted inpatients with renal insufficency, probenecidslows tubular secretion of most.cefoperazone-exc. predominantly in bile.some are deacetylated, metabolites also possess antimicrobial activity and are excreted in urine.

Pharmacology

Cefixime exerts its bactericidal effect by attaching to penicillin-binding proteins and inhibiting peptidoglycan synthesis, thus causing damage to the bacterial cell wall.

Bioavailability	40% to 50%
Protein binding	Approximately 60%
Half-life	Variable Average 3 to 4 hours
Excretion	Renal and biliary

Mechanism Of Action

Cefixime is a semi-synthetic, oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes cephalexin (Keflex), cefaclor (Ceclor),cefuroxime (Zinacef), cefpodoxime (Vantin), cefprozil (Cefzil), and many injectable forms. Like other cephalosporins, cefixime stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together; bacteria cannot survive without a cell wall. Cefixime is active against a very wide spectrum of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae,Streptococcus pyogenes (the cause of strep throat), Hemophilus influenzae, Moraxella catarrhalis, E. coli, Klebsiella, Proteus mirabilis, Salmonella,Shigella, and Neisseria gonorrhoeae.

Side Effects

Diarrhea, Vomiting, Mild skin rash, Headache, Severe skin rash, Itching, Difficulty breathing or swallowing, Wheezing.

Warnings

In penicillin-sensitive patients, cefixime should be administered cautiously. Patients may be sensitive to penicillins and not to cephalosporins such as suprax or be sensitive to both. medical literature indicates that patients sensitive to cephalosporins are very likely to be penicillin sensitive.

Contraindications

Cefixime is contraindicated in patients with known allergies to the cephalosporin or penicillin antibiotics.