Tablet Presentation

Each film coated tablets contains:

Deflazacort IP           6 mg Deflazacort IP          30 mg

It is a corticosteroid is used in Duchenne Muscular Dystrophy. It is the inherited gene disorder that occurs due to the mutation in the dystrophin gene, as dystrophin helps to improve the muscle function, deficiency of this gene results in the weakening of the muscles .

Indications

duchenne muscular dystrophy

Mechanism of Action

Deflazacort is a prodrug and is metabolized to 21- deflazacort which is its active form, binds to the glucocorticoid receptors to exert its anti-inflammatory effect and immuno- suppressive property.

Pharmacokinetics

Absorption - It is rapidly absorbed orally
Protein binding - It is 40% bound to plasma proteins
Metabolism- It is metabolized to 21- deflazacort
Excretion- It is excreted mainly via urine .

Side effects

• Weight gain
• Back pain
• Fever
• Constipation
• Anorexia
• Abnormal behavior

Contraindications

• Contraindicated in people with known hypersensitivity
• Contraindicated during third and second trimester of pregnancy

Storage

Store it at room temperature away from light, heat and kept it at closed container.