Tablet Presentation

Each film coated tablet contains:
Lansoprazole IP           15 mg
Lansoprazole IP           30 mg

• Lansoprazole is the proton pump inhibitor and structurally is the Substituted benzimidazoles . It reduces the excessive gastric acid production by inhibiting the H+ K+ ATPase activity.
• It do not effect the enzyme pepsin and juice motility, gastric motility.
• It is more potent then than the omeprazole

Indications

• Peptic ulcer
• Bleeding peptic ulcer
• Stress ulcers
• Gastroesophageal reflux disease
• Zollinger- Ellison syndrome
• Aspiration pneumonia

Mechanism of Action

Lansoprazole rearranges itself in the cationic form i.e is sulphenic acid and sulphenamide which then reacts with the SH groups of the H+K+ATPase and inactivate the pump.

Pharmacokinetics

Absorption: It is orally absorbed, its absorption delays with the intake of food.
Protein binding: It is about 97% bound to serum proteins.
Metabolism: It is metabolized in the liver to 5- hydroxy lansoprazole and to sulphone derivative of the lansoprazole.
Excretion: It is excreted via urine.

Side Effects

• Nausea
• Loose stools
• Abdominal pain
• Muscle and joint pain
• Dizziness
• Rashes

Contraindication

• Contraindicated in the people with the known hypersensitivity.
• Contraindicated in gastric cancer
• Contraindicated in rebound acid hypersecretion
• Contraindicated in the hepatic disease
• Contraindicated in pregnancy

Storage

Store it at room temperature.

Disclaimer:The data uploaded is made from content already available on internet.The company holds no right of it and is not responsible for any wrong information.